Drug Delivery–mediated Control of RNA Immunostimulation
نویسندگان
چکیده
منابع مشابه
Modifications in small interfering RNA that separate immunostimulation from RNA interference.
Synthetic small interfering RNA (siRNA) can suppress the expression of endogenous mRNA through RNA interference. It has been reported that siRNA can induce type I IFN production from plasmacytoid dendritic cells, leading to off-target effects. To separate immunostimulation from the desired gene-specific inhibitory activity, we designed RNA strands with chemical modifications at strategic positi...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2009
ISSN: 1525-0016
DOI: 10.1038/mt.2009.147